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Current technologies for producing influenza vaccines in
fertilized chicken eggs or by using cell culture-based
manufacturing are characterized by:
- Low yields
- Overall lack of production capacity
- Long lead time between identification of new virus
strains and the manufacture of the bulk quantities needed
for flu epidemic or pandemic
- Impracticality of egg-based production for avian H5N1
vaccine because of high virulence to chickens and eggs
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