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Plant-based production of antifibrotic peptides receives U.S. patent

January 30, 2021

Scarring, or fibrosis, can lead to organ failure and is the end stage of many diseases, including lung, liver and heart disease. Before coming to MUSC, Carol Feghali-Bostwick, Ph.D., the Kitty Trask Holt Endowed Chair for Scleroderma Research and a professor of medicine, identified antifibrotic properties of a peptide that not only stopped fibrosis but reversed it in mice and cultured human tissue.

The peptide was licensed to iBio Inc., a biologics company that develops therapeutics in plants. Since then, iBio has been producing the protein using a plant-based system. In November 2020, MUSC, iBio and Novici Biotech received a U.S. patent on plant-based production for the peptide that is being developed by iBio. This novel production method is inexpensive and should ensure an adequate supply of the peptide for clinical trials and later for clinical use.

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Customized Glycoengineering in Plant-Based Expression Systems

January 8, 2021

The past few years have seen an explosion in interest in immuno-oncology approaches that leverage monoclonal antibodies (mAbs) as therapeutics for a range of cancers. These therapies take advantage of the ability of antibodies to trigger antibody-dependent cellular cytotoxicity (ADCC) within the innate immune response, in which the patient’s immune cells (predominantly natural killer T cells) respond to the binding of the mAb to antigens on the surfaces of cancer cells by actively lysing the cancer cells.

Recent research has shown that the glycosylation state of therapeutic antibodies––particularly fucosylation––can modulate the activity of the antibodies and thus the robustness of the ADCC response. The Fc region of mAbs functions as a critical bridge between the adaptive and innate immune response, notably including the activation of ADCC via natural killer Tcells.

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Exploring Plant-Based Bioreactors for Developing COVID-19 Therapeutics and Vaccines

October 2, 2020

Biologics company iBio, is focused on developing therapeutics and vaccines using a novel plant-based system. It recently announced a worldwide licensing agreement with Planet Biotec> to develop and manufacture a novel COVID-19 therapeutic calledACE2-Fc.

Technology Networks spoke with iBio’s CEO and Chairman of the Board Thomas Isett, to learn more about the company’s efforts to develop ACE2-Fc as well as two vaccine candidates IBIO-200 and IBIO-201 against SARS-CoV-2. Isett also discusses the key benefits of plant-based manufacturing and highlights additional disease areas that they are working to develop biotherapeutics for.

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The Advantages of Implementing Plant-Based Vaccines

September 29, 2020

Accelerated development of vaccines is essential to public health and pandemic preparedness, both for the current COVID-19 pandemic and future threats. iBio is developing multiple vaccine platforms — using its, readily scalable FastPharming® plant-based production system with the hope of providing long-term immunity without the safety concerns presented by DNA- and RNA-based vaccines.

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