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CDMO Services

Bioanalytics

Bioanalytics and Protein Characterization Expertise

Supporting today’s ideas and tomorrow’s biotherapeutic solutions

As developers explore an increasingly diverse array of biotherapeutic molecule types and configurations, a partner with the capacity for efficient turnaround, state-of-the-art instrumentation and techniques, and a highly-skilled bioanalytics and protein characterization team is needed. Our bioanalytics team is here to meet these demands.

While clients trust us to deliver dependable and reliable bioanalytical services, we’ve never accepted the status quo. Whether exploring alternative approaches to protein production via our FastPharming® plant-based protein expression system, using our Glycaneering™ service to tailor and control N-glycosylation for next-generation antibody engineering, or leveraging mass spec multi-attribute methodology to improve efficiency, we have a unique perspective on the world of biotherapeutics.

To support great biotherapeutic ideas, no matter the routes utilized and who is developing them, our bioanalytical services team is here to help advance biotherapeutic research and development.

Looking for a Bioanalytical Services or Protein Characterization Partner?
Contact Us To Discuss Your Project

Our experienced bioanalytical team can analyze an array of sample types including:

Recombinant proteins

Monoclonal, polyclonal & bispecific antibodies

Bioconjugates

Oligonucleotides

Pegylated peptides

Antigens for subunit vaccine design

Virus-like particles (VLP)

Enzymes

Blood factors and cytokines

Bioanalytical Capabilities

Bioanalytical Capabilities
Equipment/Method
Data Samples
Bioanalytical Capabilities
Intact Protein Analysis

Protein proteoform determination

  • Intact analysis of glycoforms
  • Intact analysis of protein alone (de-glycosylated)
Equipment/Method

Reverse phase HR/LCMS on a Sciex X500B TOF/5600 TOF mass spectrometer

Data Samples
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Bioanalytical Capabilities

Middle-down characterization for monoclonal antibodies

  • Heavy chain and light chain analysis (HRMS and CZE)
  • iDes digest for analysis of Fab and Fc regions
Equipment/Method

Reverse phase HR/LCMS on a Sciex X500B TOF/5600 TOF mass spectrometer

Data Samples
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Bioanalytical Capabilities
Bottom-up Proteomic Assays

Amino acid sequence confirmation

  • Identification of post-translational modifications
  • Peptide mass fingerprinting
  • Glycopeptide identification
Equipment/Method

Reverse phase HR/LCMS on a Sciex X500B TOF/5600 TOF mass spectrometer

Data Samples
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Bioanalytical Capabilities
N-glycan profiling

Released glycan analysis by HR/LCMS and CZE with LIF detection

Equipment/Method

HILIC HR/LCMS on a Sciex X500B TOF/5600 TOF mass spectrometer and LIF detection on Sciex CESI CZE unit.

Data Samples
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